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The interaction between the Gly-His-Lys peptide and fibroblasts is believed to potentially initiate a cascade of biological events leading to the synthesis of collagen, thereby playing a potential role in the mechanisms of tissue repair and regeneration

J Funct Foods 85:104614 Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ (2019) Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects

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On the other hand, phosphatidylserine exposure in malaria-infected eryptotic cells promotes interactions with endothelial cells with the negative impact on their function [229]