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and (3) their systemic roles beyond the liver can complicate safety profiles

Obesity-related inflammatory imbalance elicits follicular occlusion and HS progression through multiple molecular mechanisms [147]

For healthcare providers and patients alike, the message is clear: careful screening for pre-existing gastrointestinal conditions, a thorough discussion of potential risks, and prompt reporting of severe or persistent GI symptoms are essential components of safe and responsible medication use

PMCID: PMC8789089