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It binds to GLP-1 receptorsG proteincoupled receptors widely distributed in pancreatic -cells, gastrointestinal smooth muscle, the central nervous system, heart, kidney, adipose tissue, and reproductive organs

Patients should talk to their healthcare provider about any mental health concerns

Coverage details: Contact your insurance provider to understand your coverage for GLP-1 agonists and any required pre-authorization

The doses studied in clinical trials range from 1mg to 12mg, with 12mg being the highest dose tested and producing the greatest weight loss (-24.2% at 48 weeks in Phase 2, -28.7% at 68 weeks in Phase 3)

When blood sugar is high, GIP has minimal effect on glucagon