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In biological systems, over 95% of circulating native IGF-1 is sequestered in ternary complexes with IGF binding proteins (primarily IGFBP-3) and the acid-labile subunit (ALS), meaning only a small free fraction is available to activate IGF-1R at any given time
Focus on: Protein-rich foods at each meal (lean meats, fish, eggs, legumes, dairy) to preserve muscle mass during weight loss High-fibre vegetables and whole grains to support digestive health and provide sustained energy Adequate hydration aim for 6-8 glasses of fluid daily, as recommended by the NHS (individualised advice may apply if you have heart or kidney conditions) Smaller, more frequent meals if large portions trigger nausea Limiting ultra-processed foods, added sugars, and excessive saturated fats The NHS Eatwell Guide provides an excellent framework for balanced nutrition whilst taking GLP-1 medications
If muscle preservation is a top concern for you, adding a structured fitness routine and adequate protein intake will be essential regardless of whether you choose Semaglutide vs Tirzepatide
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Ruiz-Colon et al, 2014) Toxic Effects: May cause physiologic dependence & withdrawal symptoms after abrupt discontinuation (e.g
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