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Overall there are four different pathways: (a) the transcellular route used by small hydrophilic and lipophilic compounds

A.WangC.WuH.BosmaA.et al (2020)

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Microneedles (MNs), as a minimally invasive, painless, and user-friendly transdermal delivery platform, offer a promising alternative for localized therapy in RA [31]

and consequently brings a series of beneficial alterations defined as bifidogenic effects ( Desulfovibrio spp