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Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control: Role of Proximal Tubule Na + /H + Exchanger Isoform 3, Renal Angiotensin II, and Insulin Sensitivity

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GLP-1 Monotherapy Exenatide Exenatide (Byetta, Bydureon) was the first approved GLP-1 analogue in 2005, a synthetic form of the naturally occurring peptide exendin-4 first isolated from Heloderma suspectum (Gila Monster) lizard venom in 1992 [25]