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IRS-1 acts as a critical crosstalk mediator between IGF-1R and FGFR1 pathways, encompassing a feedback loop between IRS-1 and MAPK/ERK (3)

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The section below ranks products against those four objective standards

Prenatal administration of IGF-1 in pregnant wild type (WT) mice results in increased body weight, higher breast density with longer ductal elongation and higher breast stem/progenitor cell populations of prepubescent offspring compared to phosphate buffered saline (PBS) controls [54]