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Where these Approaches Might Work Together Clinicians often combine therapies to balance efficacy, side effects, and cost

Velsor LW, van Heeckeren A, Day BJ: Antioxidant imbalance in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice

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Notably, LEO downregulated ACADM , NDUFB8 , SOD2 , COX4I1 , and SDHB (involved in fatty acid oxidation and ROS detoxification), while concurrently upregulating IDH3A , GPX1, CPT1A, PDK4, and MPC1/2 (critical for TCA cycle flux and pyruvate metabolism)

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Targeting the Pathways of Regulated Necrosis: a Potential Strategy for Alleviation of Cardio-Cerebrovascular Injury