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Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)

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308,362,363,372,434,435,436 Additionally, EULAR guidelines recommend losartan for patients with hypertension and fenofibrate for those with hyperlipidemia, both of which have mild uricosuric effects

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Jain NK, Tailang M, Jain HK, Chandrasekaran B, Sahoo BM, Subramanian A, et al