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PMCID: PMC12314384

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Non-canonical GH-GHR intracellular signaling is typically independent of JAK2, and involves recruitment of Src family non-receptor tyrosine kinases (45), stimulation of phospholipase C (PLC) and via cytosolic calcium flux from organelles, activation of protein kinase C (PKC) (47)

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Results Sequence variations in monotreme Gcg genes are present in regions known to be important for the regulation of protein function Gcg , Glp-1r , Gip and Dpp-4 genomic sequences were identified in the platypus genome database