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Persistent or worsening reactions warrant a clinician check

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [published correction appears in Lancet

And by that we really mean products and strategies that are addressing demographic challenges around aging populations

I take a little comfort that GLP-1 is a naturally occurring hormone, although we are giving it as a peptide and now as a small molecule orally, so it's not a compound that's foreign to the body, although at higher doses in individuals