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Metabolic rate is lower in this group, so caloric deficit management requires more attention

Baseline nausea, reflux, or inflammatory bowel conditions amplify GI side effect risk

The Phase 2 trials enrolled people with a BMI of 27 or higher with at least one weight-related condition, or a BMI of 30 or higher without additional conditions

For many patients, dry mouth symptoms improve over time as the body adjusts to the medication, particularly if good hydration practices are maintained.

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis