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Chemical depletion of glutathione in vivo
Consistent dosing per vial
Notably, effects were achieved via multiple routes of application including intragastric and local, suggesting broad applicability across experimental delivery methods
Conversely, in myocardial IRI, activation of LDHA has been found to phosphorylate and stabilize the ferroptosis-suppressing enzyme GPX4 via its kinase activity, suggesting that direct inhibition of LDHA could be detrimental (48)
The direction of travel is towards more enforcement, not less
Neuropharmacol ., 38 (1), 1117
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