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Each form differs in how it is absorbed and utilized by the body

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[1] It is important to distinguish true allergic reactions from common medication side effects, as gastrointestinal symptoms are expected with tirzepatide therapy and do not typically indicate allergy unless accompanied by other hypersensitivity features

This is higher than other GLP-1s, which had discontinuation rates of 6.1% (tirzepatide), 8.0% (semaglutide) and 10.3% (orforglipron)

Although no clinical studies have yet evaluated the combination of GLP-1RAs and isotretinoin, the overlap is growingespecially among adolescents

Su Y, Tian X, Gao R, Guo W, Chen C, Chen C, et al