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It is not merely a simple bidirectional link between the brain and the gut but a comprehensive regulatory system interwoven across multiple systems and signaling pathways

Patients interested in trials should speak to their GP or search via NIHR Be Part of Research

Sirt1, Sirt6 and Sirt7 are predominantly localised in the nucleus, while Sirt2 is found in the cytoplasm, and Sirt3, Sirt4 and Sirt5 are found in the mitochondria (Yu et al., 2022)

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On GLP-1, digestion is slower and less predictable

Bouter Y, Liekefeld H, Pichlo S, Westhoff AC, Fenn L, Bakrania P, et al