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Dysfunction of GPX4 has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases

More successful mitigation of oxidative than nitrogen stress in the brain could also contribute to findings that chronic sleep loss is sufficient in and of itself to drive neuron loss in many brain regions (Owen and Veasey, 2020), despite most oxidative stress accumulating in the gut rather than the brain during chronic sleep loss (Vaccaro et al., 2020)