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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells

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Biomed Pharmacother 89:11961206 El Morsy E, Ahmed M (2020) Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

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