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Identifying GLP1R and GIPR in endothelial cells, vascular smooth muscle cells, and blood has underscored their significant roles in vascular function [11]

Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3 signaling

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doi: 10.1016/j.jada.2010.05.009 75 DellschaftNSRichardCLewisEDGorukSJacobsRLCurtisJMet al

Additionally, if your genetic testing reveals strong genetic drivers of appetite (such as GIPR rs1800437 variants that amplify glucose-dependent insulin secretion signals), a higher dose may better match your physiology