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Its primary activity is CNS-based

One of the key advantages of Tesamorelin lies in its ability to address a specific medical need while minimizing off-target effects

(2020) Acta Crystallogr D Struct Biol 76 : 1222-1232 PubMed: 33263328 Search on PubMedSearch on PubMed Central DOI: PubMed Abstract: The growth of diffraction-quality crystals and experimental phasing remain two of the main bottlenecks in protein crystallography

Some small molecule TrkB agonists like LMDS-1 and LMDS-2 have shown BBB permeability in parallel artificial membrane permeability assays (Chiu et al., 2022)