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Richie JP Jr., Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, et al

10.1146/annurev-neuro-061010-113613 88 OlgunA

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Its primary function is to help your body turn fat into energy

As a central transcription factor, NRF2 influences this cell death mode by inducing a variety of genes including SLC7A11, GPX4, FSP1, NQO1, HMOX1, ferritin heavy chain 1 (FTH1), HECT and RLD domain-containing E3 ubiquitin protein ligase 2, and vesicle-associated membrane protein 8 in hepatocellular carcinoma and ovarian cancer cells [85, 86]

Emerging approachesstem cell therapy, CRISPR-Cas9, and AI-enhanced diagnosticsshow promise