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GLP-1 and alcohol in animal models GLP-1R activation has been shown to reduce alcohol consumption, alcohol reward, and motivated alcohol seeking

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The early presence of IgG subtypes has been observed in some patients 86 , indicative of a possible memory to a cross-reactive antigen in a secondary immune response that might increase disease severity due to ADE 86,87

Local administration is commonly used because its effects appear strongest close to the target tissue