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Interestingly, autoreactive IgG1 is found in serum early in the clinical development of pemphigus foliaceus, and a subclass switch to IgG4 has been postulated to be an important pathological driver [169]

These are then oxidized into CO 2 and H 2 O through mitochondrial -oxidation, TCA cycle, and electron transfer

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doi: 10.1016/j.jaci.2020.08.017 65 Di DonatoGdAngeloDMBredaLChiarelliF

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