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Similarly, others have defended drug levels as matching plasma levels in humans and not acknowledged the short half-life of metformin

doi: 10.1016/s1542-3565(05)00017-0

Diabetes 54 , 190196 (2005)

Ideally, an effective combination drug therapy for treating obesity would enhance the magnitude and temporal duration of weight loss but would also engage a set of partially-overlapping, complementary neural circuits to mechanistically suppress feeding

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