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PubMed: 35975308Clinical (RCT / meta-analysis) ref-3.Lizzo G, Migliavacca E, Lamers D, Frezal A, Corthesy J, Vinyes-Pares G, Bosco N, Karagounis LG, Hovelmann U, Heise T, von Eynatten M, Gut P A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage
Similarly erroneous are widely popularised views that reactive glia polarise into simple opposing functional states that are either good or bad, neuroprotective or neurotoxic, pro-inflammatory or anti-inflammatory, A1 or A2, and M1 or M2
This increased glutathione pool may help contend with the increased flow of free radicals from dysfunctional mitochondria
In particular, OS induces the production of oxidized DNA adducts, such as 8-hydroxy-2-deoxyguanosine (8OHdG) within the DNA, resulting in single- or double-strand breaks (140)
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Kanberg, N
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