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Structural features that allow oral absorption include cyclic backbone, N-methylation, D-amino acid substitution, and molecular weight under roughly 500 daltons

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Although both dysregulated hepatic glutathione homeostasis and TNF overproduction are critically involved in the development of NAFLD, whether they can be synergistically implicated in hepatocyte death remains to be clearly defined

The four components span distinct structural classes and non-overlapping pathway layers signaling, ECM remodeling, cytoskeleton, and inflammation