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The biggest downside would be the natural fishy odour that puts some people off

Intranasal brain delivery of cationic nanoemulsion-encapsulated TNF siRNA in prevention of experimental neuroinflammation

Zhang YC, Tang Y, Chen Y, Huang XH, Zhang M, Chen J, Sun YG, Li YG

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BPC 157 may reduce systemic inflammatory responses, while TB500 aids in the resolution of local inflammation at tissue damage sites

The absence of effects on IGF-1, glucose metabolism, and tissue growth reduces concerns about long-term hormonal consequences, but prudent medical oversight remains appropriate for any extended peptide use