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The proposed mechanism for the benefits of GLP-1 RAs in HS appears to involve both weight reduction and direct effects on the immune system [33]

Crucially, current evidence remains correlational

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Semaglutide has a long half-life, meaning it stays active for days

Seino Y, Yabe D, Sasaki T, et al

When to Switch Compounds or Adjust Your PlexusDx Treatment Plan If you've been on therapeutic-dose semaglutide (1.7-2.4 mg weekly) for 3+ months with inadequate weight loss or weight gain, a protocol adjustment is warranted