Atkinson RW, Butland BK, Anderson HR, Maynard RL
For example, GluK2 and GluK5 are expressed in the majority of hippocampal neurons, as well as in various types of interneurons (Paternain et al., 2000), GluK1 exhibits widespread expression in cerebellar cortex and olfactory bulbs during early development (Pinheiro et al., 2007), and GluK4 is mainly present in the pyramidal neurons of the DG and Cornu Ammonis 3 (CA3) region of hippocampus and in the amygdala (Lerma and Marques, 2013
AIMS Microbiol 3:155170
Endogenous importance does not validate every product Water, glucose and insulin are also endogenous or physiologically essential, but their medical effects depend on dose, route, formulation, diagnosis and product quality
GHK-Cu has been shown in cell culture to increase dermal papilla cell proliferation and protect these cells from programmed cell death (apoptosis), shifting the Bcl-2/Bax survival balance in favor of cell protection
This is one of the first studies to demonstrate a mechanism for long-term presynaptic plasticity at GABAergic synapses