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That distinction matters because it means the aesthetic profile of each drug tracks closely with how much and how fast weight is lost

Any changes people notice may be due to placebo effects, increased awareness around eating, or temporary water weight changes rather than true fat loss

To reduce the GI side effects, which mainly occur in the early dose escalation period, semaglutide is given in increasing doses by a prefilled pen by self-injection under the skin (abdomen, thigh or arm) starting at 0.25 mg for a month and gradual increases each month reaching the maximum dose of 2.4 mg at month 5

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