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Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma

PMID 10368185

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Through glutathione S-transferase (GST) enzymes, GSH can conjugate (bind) to certain reactive metabolites and environmental compounds, making them more water-soluble and easier for the body to eliminate

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