l carnitine effect on thyroid L-carnitine supplementation at doses of 2–4 g/day has been shown in a randomized, double-blind, placebo-controlled trial by Salvatore Benvenga to reverse and prevent symptoms of iatrogenic hyperthyroidism in women receiving TSH-suppressive levothyroxine l carnitine for subclinical hyperthyroidism

Abbreviations % DL : Drug loading % EE : Encapsulation efficiency 8-OHdG : 8-Hydroxy-2-deoxyguanosine ANOVA : Analysis of variance ApoE : Apolipoprotein E ApoE-MiADMSA-LPS : ApoE-coated monoisoamyl dimercaptosuccinic acid-loaded liposomes BBB : Blood-brain barrier BBD : Box-Behnken design CAT : Catalase CCSEA : Committee for Control and Supervision of Experiments on Animals COX : Cyclooxygenase Cp : Ceruloplasmin Cu : Copper CuSO 4 : Copper sulfate CV : Central vein DAPI : 4,6-Diamidino-2-phenylindole DMEM : Dulbeccos modified Eagle medium DMSA : Dimercaptosuccinic acid DMSO : Dimethylsulfoxide DSC : Differential scanning calorimetry EDTA : Ethylenediaminetetraacetic acid ELISA : Enzyme-linked immunosorbent assay EPM : Elevated plus maze FBS : Fetal bovine serum FITC : Fluorescein isothiocyanate FTIR : Fourier transform infrared spectroscopy GSH : Glutathione H&E : Hematoxylin and eosin stain IAEC : Institutional animal ethics committee LPS : Liposomes MiADMSA : Monoisoamyl dimercaptosuccinic acid MDA : Malondialdehyde MiADMSA-LPS : Monoisoamyl dimercaptosuccinic acid-loaded liposomes MTT : 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MW : Molecular weight MWM : Morris water maze NORT : Novel object recognition test PBS : Phosphate buffer saline PDI : Polydispersibility index RNS : Reactive nitrogen species ROS : Reactive oxygen species SD : Standard deviation SEM : Scanning electron microscopy SOD : Superoxide dismutase TEM : Transmission electron microscopy TETA : Triethylenetetramine WD : Wilson disease References Azmand MJ, Rajaei Z (2021) Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats

Ethical approval Ethical approval was obtained from the Institutional Animal Ethics Committee at the College of Veterinary Medicine, University of Baghdad (approval no

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10.1371/journal.pone.0263149 PLoS One