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Nitrosoglutathione (GSNO) and protein nitrosothiols (PSNO) are also formed in cells and play a role in NO signaling independent of the cyclic GMP pathway

Some reviews note no apparent effect on pregnancy in sensitivity analyses, underscoring the gap between biologic plausibility and durable clinical benefit

Injections are more effective, and the results from pills and creams are not long-lasting as injections

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