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Compounded semaglutide preparations are mixed by pharmacies for individual patient dispensing, a practice Health Canada has stated is not permitted for GLP-1 receptor agonists prepared from synthetic active pharmaceutical ingredients

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No regulatory approvals exist for this indication

Moreover, SLE patients with renal involvement exhibited significantly higher serum KYN levels and KYN/TRP ratios than those without renal damage, suggesting that activation of the kynurenine pathway may exacerbate glomerular mesangial cell injury via pro-oxidative mechanisms [51] (Fig