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Novo Nordisk pushed back, arguing the study focused on diabetes patients, not those treated specifically for obesity, and lacked clarity on dosing

Among the most widely used mechanisms are reduction-sensitive disulfide (-SS-) and diselenide (-SeSe-) linkages, which can be cleaved by intracellular GSH to activate drug release or imaging functions [16]

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The study reports that food and morphine-derived opioid peptides can modulate cysteine uptake with subsequent effects on cellular redox and methylation status, leading to global changes in DNA methylation and gene transcription [161]

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