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The science of neuroendocrinology was advanced conceptually 50 years ago by the independent discoveries of Schally, Leeman and Reichlin, demonstrating that the gut peptides thyrotropin-releasing hormone (TRH) ( The BBB does not impair access of sex steroids to the CNS to the same extent as gut peptides

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A central aspect of this signaling pathway is acetyl-L-carnitine (LAC), a pivotal mitochondrial metabolite best known for its role in fatty acid oxidation