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Additionally, cholesterol is a precursor in the biosynthesis of steroid hormones, including glucocorticoids, mineralocorticoids, and sex hormones and, for this reason, contributes to the intra-tumoral synthesis of androgens [327, 331,332,333,334]

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Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

However, excessive or systemic induction of ferroptosis may cause normal tissue toxicity and impair immune cell function, emphasizing the need for precise spatiotemporal control in therapeutic regimens