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Add in individual predispositions, and things get even trickier

Previous research has shown that immuno-metabolic dysregulations map more consistently to symptoms of the atypical spectrum characterized by altered energy intake/output (in particular the reversed neurovegetative symptoms of hyperphagia, hypersomnia with leaden paralysis and fatigue) [2] and symptoms of anhedonia [33]

For instance, the participants mean score of MMSE was very low (16.5) and the subjects had cognitive impairment, 21 whereas in this study, the mean score of MMSE, which was very high (27), indicated a normal cognitive function

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Messer also believes that when it comes to hormones, how much GLP-1 you have naturally isnt actually whats driving weight gain or inhibiting weight loss