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Once inside the cell, the -glutamyl-amino acid can be metabolized to release the amino acid and 5-oxoproline, which can then be converted into glutamate to be used in the synthesis of GSH
Schmidt-Supprian, M
The release of mitochondrial DNA (mtDNA) activates the cGAS-STING signaling axis, which then triggers macrophages in RA to secrete tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6) [21]
Analysis of oxidative stress levels in the prefrontal cortex ELISA analysis revealed that valproic acid (VPA) exposure significantly disrupted oxidative stress homeostasis in the prefrontal cortex of SD rats