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Health regulatory agencies such as the United States Food and Drug Administration (FDA), the European Medicines Agency (EMA), and the Pharmaceuticals and Medical Devices Agency of Japan (PMDA) evaluate data from clinical trials before approving the use of GLP-1 analogs for the treatment of diabetes and obesity

Breastfeeding women should also avoid it due to unknown excretion into breast milk

Studies have also reported stimulation of proteoglycan and collagen synthesis in chondrocyte preparations, pointing to a meaningful role in joint research independent of its metabolic activity

Turner et al., 1988, 1990

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Research shows that as you lose weight, your metabolic rate often slows down