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These genomic alterations enable Leishmania to develop resistance through various mechanisms including altered drug transport, target modification, and enhanced metabolic detoxification pathways (Ponte-Sucre et al., 2017)

Zambernardi A, Label M (2018) Cutaneous adverse drug reactions: how to identify the trigger

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B12 doses ranging from 500-1000 mcg, with methionine, inositol, and choline ratios adjusted per formula

Addressing these gaps necessitates further investigation and analysis in future studies