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All three are actively transported into proximal tubular cells via organic anion transporters (OAT1/3), where they trigger oxidative stress through NADPH oxidase activation and reactive oxygen species (ROS) generation (115, 124)

10.1038/nrrheum.2017.50 79 MorelF.RoussetF.Vu Chuong NguyenM.TrocmeC.GrangeL.LardyB

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Vitamin C is perhaps our most important antioxidant

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