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You can find genetic testing with various companies such as 23andme.com Its estimated that those with one mutation (heterozygous) decrease their ability to methylate by 30% and those with two mutations (homozygous) decrease their ability to methylate by 70%, making it virtually impossible to get adequate B12 from diet alone (19)

In cases of inoperability, radiotherapy, imiquimod, 5-flourouracil, photodynamic and target treatment for the hedgehog pathway can be other options for treatment (37)

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Potential considerations include: Mixing marijuana or combining marijuana with SSRIs may increase the risk of side effects due to changes in medication levels