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Mechanistically, semaglutide monotherapy suppressed mitochondrial gene expression and elevated atrophy-related genes

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While GH therapy is more commonly used in clinical settings, IGF-1 can also effectively reverse skeletal growth discrepancies [31,163,184192]

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Safety and Tolerability Across trials, retatrutides most common side effects were mild to moderate gastrointestinal issues (nausea, vomiting, diarrhea, constipation), particularly during dose escalation