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Extreme caloric restriction while on semaglutide can lead to muscle loss, nutritional deficiencies, and metabolic adaptation that makes long-term weight maintenance harder

[4] Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), but also neutral endopeptidase 24.11 and renal clearance, resulting in a half-life of approximately 2 minutes

Unlike daily medications, this weekly format reduces the burden of remembering doses and creates a predictable routine

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Almasieh M, Levin L (2017) Neuroprotection in glaucoma: animal models and clinical trials

She's also embraced exercise for the first time in her life