5-HT 4 receptor agonists Prucalopride, a selective 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonist, was effective in improving symptoms in a cohort with predominantly idiopathic gastroparesis, but despite accelerating gastric emptying in a diabetes-specific group, did not improve symptoms [73]
The logic is sound: you get concentrated local delivery to the target tissue plus systemic support for the repair machinery behind it
They are also involved in presynaptic transmission, and they regulate calcium concentration during signal transduction (Picone et al., 2014)
The findings were notable
The same source reports that orlistat (Xenical) produced an average 8% body weight loss after 56 weeks in people following a reduced-calorie diet, compared with 4% with placebo
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