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First cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM and high cardiovascular risk, showing that saxagliptin does not augment MACE but increases hospitalization for heart failure

The highest risk appears to be in patients with type 2 diabetes who have established diabetic retinopathy at the time of treatment initiation, particularly when aggressive glycemic targets are pursued rapidly without appropriate ophthalmologic monitoring

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Adding vitamin C helps extend those benefits by recycling the glutathione back into its active state

From the above discussion of PI3K/AKT/mTOR, Wnt/-catenin, and NF-B pathways, we focused on the direct interactions of LPO products with these pathways and their impact on cancer progression

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