4) highlighted the possibility of growing the compound towards the TIN2 phenylalanine binding pocket
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Although these oxygen groups introduce defects that slightly weaken the intrinsic strength of GO, they also enhance its interactions with polymers and other materials, making it an excellent reinforcement agent in nanocomposites.In contrast, amorphous GO with a similar oxygen coverage exhibits a slightly lower variation, with values between 290 and 430 GPa 143
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Through multi-target mechanisms, these active metabolites either directly activate the -catalytic subunit of AMPK (via phosphorylation at Thr172) or indirectly modulate upstream kinases (such as LKB1 and CaMKK ), thereby influencing the expression and activity of downstream key effector molecules, including ACC, SREBP-1c, and PPAR
