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Clinical opinion: the biologic and pharmacologic principles of estrogen therapy for symptomatic menopause

Wu TT, Chirieac LR, Abraham SC, Krasinskas A, Wang H, Rashid A, Correa AM, Hofstetter WL, Ajani JA, Swisher SG

Evaluate alternative therapies or pause strategies with an ob gyn or prescribing clinician if severe vaginal changes continue

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Obesity 18 , 2126 (2010)

There were many identified differences in outcomes and recommendations across numerous case reports and case series, cross-sectional, casecontrol, and cohort studies, literature and narrative reviews, systematic reviews, etc., which made it challenging to delineate clear information that was consistent across all articles and studies