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doi: 10.1038/s41589-020-0483-3 125 HofmannKDukerMFinkTLichterPStoffelW

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Somministrando in questo modo il principio attivo a livello del derma si ottiene una diffusione pi lenta del farmaco, con la possibilit di utilizzare dosi minime ottenendo al contempo un'intensa azione locale in grado di permanere tale per molte ore