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Various general autoantibodies have also been identified in ME/CFS, such as those against cellular components including anchorage molecules (514), HSP-60 (515), microtubule associated protein 2 (516), cardiolipin in 92-95% of ME/CFS patients in two studies (509, 510) but only 4% in another study (506), and neo-antigens (517)

Before receiving folic acid or methylcobalamin, patients should be assessed for deficiency and appropriate therapy started concurrently

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